Print Share on: Evidence. Both compounds are susceptible to nitrosation and can form nitrosamines in the presence of nitrosating agents.
Some potential for hazards to health or the environment. Study no.
Modification in voluntary filing of cosmetic product ingredient and cosmetic raw material composition statements, N-nitroso-N-methyldodecylamine and N-nittoso-N-methyltetradecylamine in hair-care products, Studies of in vitro cell transformation and mutagenicity by surfactants and other compounds, The carcinogenic effect of nitrosomethyldodecylamine in European hamsters, Induction of urinary bladder tumors in rats by administration of nitrosomethyldodecylamine, Induction of carcinogenesis in Fischer rats by methyl- alkylnitrosamines, Carcinogenesis by exposure to nitrites and amines, Induction of tumors in rats by feeding nitrosatable amines together with sodium nitrite, Utility of amine oxides in oil/water cosmetic systems, The production of malignant primary hepatic tumours in the rat by feeding dimethylnitrosamine, Dermatitis from Ammonyx LO, a constituent of a surgical scrub, The acute toxicity of three oil dispersants, The absorption, tissue distribution, and excretion of dodecyldimethylamine oxide (DDAO) in selected animal species and the absorption and excretion of DDAO in man, Toxicity and carcinogenicity of N-nitroso-compounds, Comparing dodecylmethylamine oxide with stearyldi-methylamine oxide, Oil spill clean-up: the effect of three dispersants on three subtropical/ tropical seagrasses, A comparison of the elimination and biotransformation of dodecyldi- methylamine oxide (DDAO) by rats, rabbits, and man, Final Report on the Safety Assessment of Lauramine Oxide and Stearamine Oxide, https://doi.org/10.3109/10915819409141001, Amended Final Report of the Safety Assessment of Cocamidopropylamine Oxide1. (1992) Frequency of use data. Food and Drug Administration. EWG is in the process of updating this score. The international Organisation for Economoic Co-operation and Development reported that the lowest acute oral LD50 for any amine oxide tested is 846 mg/kg body weight.
*, Springborn Life Sciences, Inc. (1987) Submission of unpublished data by CTFA. 2006. EWG provides information on cleaning product ingredients from the published scientific... EWG provides information on cleaning product ingredients from published scientific literature, to supplement incomplete data available from companies and the government. Low Concern . Study no. (Received 1990) Letter regarding nitrosamine concentrations for several lots of Lauramine Oxide.
Stearamine Oxide applied to rabbit skin at 5% did not cause irritation. Rice DP; Toxicol Appl Pharmacol 39 (3): 377 (1977). Thermeidics Company, Mass.
Reproductive Toxicity . 1-dodecanamine, N,n-dimethyl-, N-oxide, 40. Acute oral toxicity (LD50) [of 0.3% Lauramine Oxide] in rats.” Test no.
N,n-dimethyldodecylamine-n-oxide Solution, 46. Human sensitization test [of a formulation containing 0.3% Lauramine Oxide]. (. The e-mail addresses that you supply to use this service will not be used for any other purpose without your consent. Metabolic profiles for different species (rat, human, mouse, rabbit) did not have any significant differences in metabolites, but the degree of absorption, especially in cutaneous applications, varied from species to species. Lean Library can solve it. Click the button below for the full-text content, 24 hours online access to download content. Personal correspondence to Dr. R. L. Elder from Dr. G. McEwen (CTFA).
If you have access to a journal via a society or association membership, please browse to your society journal, select an article to view, and follow the instructions in this box. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any.
Radioactivity was also found in the kidneys, intestine, lungs, spleen, heart, pancreas, bone marrow, leg muscles, testes, ovaries, and whole blood. Volume 5: A Review of the Literature Published during 1976 and 1977. *, Hazelton Laboratories America, Inc. (1986) Submission of unpublished data by CTFA. (1990a) Submission of unpublished data by CTFA. Safety Data Sheet (Lauramine Oxide) DATE PREPARED: 10/17/2016 Page 5 of 7 Section 11. Radioactivity was detected in the liver, kidneys, testes, blood, and expired CO2. The ratings indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations.
Lauramine Oxide is an Amine N-oxide, an active component primarily found in shampoo, bubble bath and hand soap thanks to its foam building properties . Both ingredients caused mild, transient ocular irritation in rabbits. Please check you selected the correct society from the list and entered the user name and password you use to log in to your society website. Cancer . Please read and accept the terms and conditions and check the box to generate a sharing link. Study no. For more information view the SAGE Journals Sharing page. By continuing to browse
At 0.3%, Lauramine Oxide was not a sensitizer in clinical studies.
The European Union Ecolabel program reports this substance is readily biodegradable.
At 0.3%, Lauramine Oxide was not a sensitizer in clinical studies.
*, Oak Ridge Research Institute. The ratings indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. Evaluation of the upper airway irritation potential of a test material [0.3% Lauramine Oxide]. (. The Chemical Society. Human repeated insult patch test.
Amine Oxides. The international Organisation for Economoic Co-operation and Development reported that amine oxides are not carcinogenic.
A quote from the Journal of the American College of Toxicity: “Lauramine Oxide produced severe dermal reactions in rabbits, but at 0.3% only slight to moderate erythema with slight edema, fissuring, and slight to moderate epithelial desquamation were found.”
089-0116. *, Leberco Laboratories. 191-1448.
Food and Drug Administration.
Approximately 75% of the total radioactivity was excreted within 24 hr of oral administration. Unii-lf6bkc321j Component Syelzbgxaixkhu-uhfffaoysa-n. Purifying or cleansing agents, usually salts of long-chain aliphatic bases or acids, that exert cleansing (oil-dissolving) and antimicrobial effects through a surface action that depends on possessing both hydrophilic and hydrophobic properties. National Research Council.
*, Hazelton Laboratories America, Inc. (1990) Submission of unpublished data by CTFA. The international Organisation for Economoic Co-operation and Development reported that amine oxides do not cause dermal sensitization. About the ratings: EWG provides information on cleaning product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government.
28-day sub-chronic percutaneous toxicity study in rabbits with G2926.02 [formulation containing 0.3% Lauramine Oxide]. Cutaneously administered it is absorbed by man, rats, rabbits and mice. (1989b) Submission of unpublished data by CTFA. Final Amended Report on Safety Assessment on Aminomethyl Propanol and Aminomethyl Propanediol.
Toxicological Information Information on toxicological effects Acute toxicity New login is not successful because the max limit of logins for this user account has been reached.
[Dermal irritation study of 5% active Lauramine Oxide]. Level of Concern . Urinary metabolites in rats, rabbits and humans suggested metabolism via omega, beta-oxidation of the aliphatic chain, amine oxide reduction and aliphatic, mid-chain hydroxylation. Four Sprague-Dawley rats were given intraperitoneal injections of 22 mg (methyl-14C)lauramine oxide kg (specific activity 1.3 mCi/g).
15. Contact us if you experience any difficulty logging in. *, In Vitro Alternatives, Inc. (1992b) Submission of unpublished data by CTFA.
*, Hecht SS , Morrison JB , Wenninger JA . Ninety-two percent of the applied radioactivity was recovered from the skin of the test subjects 8 hr after dosing, and 0.1 and 0.23% of the radioactivity was recovered from the excretion products of the test subjects. Rabbit eye irritation (Low volume procedure) [of 0.3% Lauramine Oxide].
Journal of the American College of Toxicology, Urinary bladder neoplasms in Syrian hamsters after administration of N-nitroso-N-methyl-N-dodecylamine, Methods for detecting carcinogens and mutagens with the Sa/monella/mammalian-microsome mutagenicity test, The relationship between mutagenicity and carcinogenicity of some nitrosamines, Mutagenicity of amine drugs and their products of nitrosation, Comparison of the carcinogenic effects of five nitrosamines in guinea pigs, Amine nitrosation and nitrosation by gaseous nitrogen dioxide, International Agency for Research on Cancer, Amine oxides. Know about technical details of Lauramine Oxide like: chemical name, chemistry structure, formulation, uses, toxicity, action, side effects and more at Pharmacompass.com.
InChI=1S/C14H31NO/c1-4-5-6-7-8-9-10-11-12-13-14-15(2,3)16/h4-14H2,1-3H3, Lauryldimethylamine oxide, Dodecyldimethylamine oxide, Lauryldimethylamine n-oxide, Ammonyx ao, Ammonyx lo, Empigen ob, Chromatography (TLC / LC / HPLC / UPLC / GC), Complete Pharmacopoeial / Compendial Testing, Bioanalytical & Biomarker Testing Services, Bioequivalence / Clinical / Pre-Clinical Testing, Calculation and Modeling of Pharmacokinetic Parameters, Protein isolation, identification and characterization, Electrical Conductivity / High Voltage Leak Detection (HVLD), Mass Flow / Mass Extraction Leak Detection, European and Japanese Pharmacopoeia (EP & JP) Container Testing, ASTM and ISTA Distribution Simulation Testing, Environmental Conditioning, Cycling and Simulation Testing, Controlled / Immediate / Modified Release, Health / Dietary Supplement (Nutraceutical), Low Temperature / Cryogenic Condition (-78 °C), Pharmacokinetics / Pharmacodynamics / Pharmacometrics, Clinical Research Translation / Validation, Pharmacovigilance / Product Lifecycle Management, High Potent / Biologic / Controlled Substance, Customization (Anodizing, Siliconization, Plastic Coating), Media / Public Relations / Communications, Methacrylic Acid - Ethyl Acrylate Copolymer, Methacrylic Acid Methyl Methacrylate Copolymer, Polyvinyl Alcohol Graft Polyethylene Glycol Copolymer, Betadex Sulfobutyl Ether Sodium Excipient, Hydroxypropyl methylcellulose acetate succinate, Cross Linked Sodium Carboxymethylcellulose, Hepatology (Liver, Pancreatic, Gall Bladder). On the basis of the available animal and clinical data, it is concluded that Lauramine Oxide and Stearamine Oxide are safe as cosmetic ingredients for rinse-off products, but that the concentration in Lauramine Oxide leave-on products should be limited to 3.7% and that of Stearamine Oxide limited to 5%.
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